Was born in 1822 in Le Locle, Switzerland, but moved to Paris at the age of sixteen to begin his training with Louis Grosclaude. He entered the Ecole des Beaux-Arts and then the atelier of François-Edouard Picot. Picot also taught William Bouguereau, Alexandre Cabanel and Léon Perrault, amongst others, and was a strong proponent of the principles of the Academic tradition.
The young artist travelled to Italy at the age of nineteen and remained there for five years. He studied at the Berlin Academy between 1843 and 1844 and then returned to Paris and began exhibiting his paintings at the annual Salon, making his debut in 1850.
Zuber-Bühler continued to exhibit prolifically throughout his career, often entering several paintings in the Salon simultaneously. He also exhibited drawings, pastels and watercolours. In 1867 he exhibited at the Pennsylvania Academy of Fine Arts, showing The Pet Kitten, and was also part of the 1877 exhibition in Philadelphia for which he received an award.
His many and various entries suggest to what extent Zuber-Bühler was interested in varying his themes and also how popular with the Salon judges and the public his works were. He continued to show at the Salon until 1891. He died on November 23rd 1896, in Paris. Throughout his career, Zuber-Bühler advanced the theories of the Academic style and adhered to his training at the Ecole des Beaux-Arts.